StoneX将Sphere Entertainment目标股价从$175下调至$125
StoneX将Sphere Entertainment目标股价从$175下调至$1252026年9月,麻省理工学院化学工程团队开发自动化脂质纳米颗粒制备平台,希望更精确地控制核酸药物载体的尺寸和形状。传统制备中,脂质与RNA溶液快速混合后形成颗粒,但要得到特定尺寸,往往需要大量试错。新方法把混合分成两步,先让颗粒生长,再加入缓冲液控制这一过程。
通过调整两步之间的停留时间,研究人员可以改变颗粒大小;改变缓冲条件则有助于调节形状。自动化系统还连接动态光散射设备,边生产边测量粒径,如果结果偏离目标,就调整参数。研究团队用这些实验数据训练机器学习模型,预测哪些条件能够得到需要的颗粒。形状测量目前仍需在自动平台之外完成。不同尺寸的载体进入体内后可能到达不同组织,因此这种制备能力有助于比较递送效果。平台改善的是研发与制造控制,并不直接证明某种新药疗效,团队正在推进相关技术的商业转化。
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